The Sources of Sodium in Rabbit Pancreatic Juice

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Abstract
Using an in vivo rabbit pancreas preparation, approximately 85-90% of the Na+ found in rabbit pancreatic juice comes directly from the circulating blood of the animal as opposed to fluids bathing the peritoneum. Data was used from radiotracer experiments in which the blood and synthetic peritoneal fluid Na was labeled with 22Na and 24Na, respectively. The appearance of various isotopes in the pancreatic juice was used to determine the relative contributions of the 2 Na sources. The preference of the in vivo pancreas for vascular Na suggests that studies of pancreatic secretory mechanisms done in vitro may not be physiologically meaningful.

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