Inhibition of human alkaline phosphatases by vanadate
- 1 July 1979
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 181 (1) , 247-250
- https://doi.org/10.1042/bj1810247
Abstract
Orthovanadate was shown to be a potent competitive inhibitor (Ki less than 1 microM) of purified alkaline phosphatase from human liver, intestine of kidney. Inhibition was reversed and full enzymic activity restored in the presence of 1mM-adrenaline. Phosphate and vanadate competed for the same binding site on the enzyme.This publication has 19 references indexed in Scilit:
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