Metabolism of d-glucuronolactone in mammalian systems. Inhibitory properties of the products of d-glucuronolactone-dehydrogenase action

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Abstract
D-Glucuronolactone was converted into D-glucaro-(1[forward arrow]4)-lactone, a [beta]-glucuronidase inhibitor, probably via the intermediate D-glucaro-(1[forward arrow]4)-(6[forward arrow]3)- dilactone, by a dehydrogenase in human-liver extracts. Similar experiments with mouse-liver extracts appeared to yield only D-glucaric acid or a non-inhibitory lactone. A strong [beta]-glucuronidase inhibitor was present in mouse liver after the intraperi-toneal administration of D-glucuronolactone. D-Glucardilactone decomposed spontaneously in aqueous solution to give 25% of D-glucaro-(l[forward arrow]M)-lactone; the percentage conversion was unaffected by human-liver homogenates, but considerably increased by mouse-liver or pig-liver fractions.