INFLAMMATORY ACTIVITIES OF SYNOVIAL FLUIDS FROM RHEUMATOID‐ AND OSTEO‐ARTHRITIS TO GUINEA PIG SKIN

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Abstract
To examine the chemical pathogenesis of rheumatoid and nonrheumatoid arthritis, the nature and inflammatory activities of 12 synovial fluids from rheumatoid arthritis and 10 from osteoarthritis were studied. Both rheumatoid and nonrheumatoid synovial fluids had high protein concentration and acid and neutral protease activities. When injected (0.1 ml, intradermally) to normal guinea pig skin, both synovial fluids induced a strong vascular permeability at 0 min, a mild one at 60 min and at 4 h mild inflammation which comprised histologically moderate leukocyte infiltration around the venules, swelling of venular endothelial cells, edema, and degeneration of collagen fibrils in the deep dermis of the guinea pig skin. These parameters of inflammation induced by synovial fluids from both arthritis were of the same degree in intensity. The identification of chemical mediators of inflammation in the synovial fluids of both arthritidics requires further study.