PLACENTAL TRANSFER OF ORG NC45 IN WOMEN UNDERGOING CAESAREAN SECTION
Open Access
- 1 June 1982
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 54 (6) , 643-645
- https://doi.org/10.1093/bja/54.6.643
Abstract
Org NC4S 60-80 μg kg−1 was administered to 20 pregnant women undergoing general anaesthesia for Caesarean section. Org NC 45 plasma concentrations were measured fluorimetrically in samples of maternal, venous and arterial cord blood obtained at delivery. The venous cord to maternal concentration ratio averaged 11% and was not influenced by the interval between induction and delivery The venous cord plasma concentration averaged 40 ng ml−1 The arterial cord concentration was less than the venous cord concentration in every instance and was undetectable in four patients. It is concluded that Org NC 45 crosses the human placental barrier to a very lmited extent and that its use during anaesthesia for Caesarean section is safe for the newbornKeywords
This publication has 2 references indexed in Scilit:
- Determination of Org NC 45 (a myoneural blocking agent) in human plasma using high-performance normal-phase liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1980
- The Emergence of ORG NC 45, 1- [(2β,3α, 5α,16β, 17β)-3, 17-BIS(Acetyloxy)-2-(1-Piperidinyl)-Androstan-16-YL]-1-Methylpiperidinium Bromide, from the Pancuronium SeriesBritish Journal of Anaesthesia, 1980