INHIBITION OF BENZO[ALPHA]PYRENE-INDUCED MAMMARY CARCINOGENESIS BY RETINYL ACETATE

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 66  (3) , 559-564
Abstract
The administration of a 250 ppm retinyl acetate dietary supplement for various periods relative to intragastric administration of 50 mg benzo[a]pyrene (BP) significantly inhibited the induction of mammary cancers in virgin female inbred LEW/Mai rats. With day of BP administration taken as time O, groups receiving the retinoid from wk -2 to +1, +1 to +90, +20 to +90, and -2 to +90 showed a significant reduction in tumor response as compared to controls. The inhibition of carcinogenesis achieved by a +1 to +20 administration schedule was temporary; the tumor yield was suppressed initially but returned to control levels by wk 60. Autoradiographic analysis of mammary glands from 50 day old rats indicated that a 2 wk exposure to supplemental retinyl acetate significantly reduced the mammary gland parenchymal cell labeling index in ductal, alveolar and terminal end bud structures. Beginning the retinyl acetate supplement 1 wk after the administration of BP significantly reduced the number of terminal ductal hyperplasias. The inhibition of carcinogenesis achieved by a short period of retinyl acetate administration before and during the period of carcinogen availability and the inhibition achieved by long-term postcarcinogen retinoid exposure may involve an antiproliferative effect on the rat mammary gland.

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