Apolipoprotein E allele frequencies in patients with late-onset sporadic Alzheimer's dementia in Hungary
- 1 January 1997
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 95 (1) , 56-59
- https://doi.org/10.1111/j.1600-0404.1997.tb00069.x
Abstract
The presence of the apolipoprotein E4 allele (apoE4) has been recognized as a risk factor for the development of presenile and senile forms of Alzheimer's dementia (AD). The apoE alleles frequency of 71 normal controls (NC), 60 demented controls (DC) and 50 senile type AD subjects was determined by polymerase chain reaction in order to get data about the apoE polymorphism of the Hungarian AD population. The apoE3/3 genotype was the most common in all groups. The apoE4 frequency was significantly higher (28%) in the AD group than that was (7% and 9%) in the NC and DC populations, respectively. No apoE4 homozygotes were found in the DC group and the number of heterozygotes was lower in the DC than in the AD group. The results are in good agreement with others in the literature and support the occurrence of an increased apoE4 allele frequency in Hungarian senile AD population.Keywords
This publication has 19 references indexed in Scilit:
- Apolipoprotein E in animal models of CNS injury and in alzheimer's diseaseTrends in Neurosciences, 1994
- Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseasesThe Lancet, 1993
- Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's diseaseNeurology, 1993
- Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.Proceedings of the National Academy of Sciences, 1993
- Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob diseaseBrain Research, 1991
- Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell BiologyScience, 1988
- Apolipoprotein E polymorphism and atherosclerosis.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1988
- Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteinsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
- Expression of apolipoprotein E during nerve degeneration and regeneration.Proceedings of the National Academy of Sciences, 1986
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984