Moderation of the platelet releasate response by aspirin
- 1 June 2007
- journal article
- Published by American Society of Hematology in Blood
- Vol. 109 (11) , 4786-4792
- https://doi.org/10.1182/blood-2006-07-038539
Abstract
Modulation of the proteins released during activation is one mechanism whereby aspirin may influence platelet-mediated human disease. We investigated the effect of aspirin on the platelet releasate using mass spectrometry and found that different agonists evoked different releasate profiles, with aspirin having a general moderating effect on the amount of protein released regardless of the agonist. These observations were confirmed for several cytokines using an antibody array approach.Keywords
This publication has 27 references indexed in Scilit:
- Angiogenin: a review of the pathophysiology and potential clinical applicationsJournal of Thrombosis and Haemostasis, 2006
- The International Protein Index: An integrated database for proteomics experimentsProteomics, 2004
- Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesionsBlood, 2004
- Activated human platelets release connective tissue growth factorThrombosis and Haemostasis, 2004
- Platelet Chemokines and Chemokine Receptors: Linking Hemostasis, Inflammation, and Host DefenseMicrocirculation, 2003
- Interleukin-7–Mediated Inflammation in Unstable AnginaCirculation, 2003
- The roles of αIIbβ3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregationBlood, 2003
- Platelet Chemokines and Chemokine Receptors: Linking Hemostasis, Inflammation, and Host DefenseMicrocirculation, 2003
- Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parametersThrombosis and Haemostasis, 2003
- More pieces of the platelet activation puzzle slide into placeJournal of Clinical Investigation, 1999