Familial aggregation of neuroectodermal and gastrointestinal tumors
- 15 November 1983
- Vol. 52 (10) , 1977-1980
- https://doi.org/10.1002/1097-0142(19831115)52:10<1977::aid-cncr2820521034>3.0.co;2-y
Abstract
A family with multiple tumors is presented. Four cases were childhood neoplasms derived from the neuroectoderm, as was a malignant melanoma in a young female and a branchiogenic cyst in her brother. He also had an early onset of an adenocarcinoma of the transverse colon. Four further cases of gastrointestinal tumors and one case of acute myelogenous leukemia had occurred in the family. One of the childhood tumors was a bilateral retinoblastoma. It is discussed as to whether the tumors in the studied family were due to a genetic factor resulting in a neuroectodermal embryopathy, or were caused by a retinoblastoma gene with a pleiotropic effect.This publication has 13 references indexed in Scilit:
- RETINOBLASTOMA IN DENMARK 1943-1958Acta Ophthalmologica, 2009
- Familial Retinoblastoma and Chromosome 13 Deletion Transmitted via an Insertional TranslocationScience, 1981
- Incidence and long term survival of children with intracranial tumours treated in Denmark 1935-1959British Journal of Cancer, 1978
- A New Familial Cancer Syndrome? A Spectrum of Malignant and Benign Tumors Including Retinoblastoma, Carcinoma of the Bladder and Other Genitourinary Tumors, Thyroid Adenoma, and a Probable Case of Multifocal Osteosarcoma2JNCI Journal of the National Cancer Institute, 1977
- Retinoblastoma and osteogenic sarcoma in siblingsCancer, 1974
- Pleiotropic effects of the gene for retinoblastomaJournal of Medical Genetics, 1974
- Bilateral Retinoblastoma: A Dominantly Inherited AffectionBMJ, 1972
- Retinoblastoma: Epidemiologic CharacteristicsNew England Journal of Medicine, 1971
- Mutation and Cancer: Statistical Study of RetinoblastomaProceedings of the National Academy of Sciences, 1971
- Soft-Tissue Sarcomas, Breast Cancer, and Other NeoplasmsAnnals of Internal Medicine, 1969