Cerebrospinal Fluid and Behavioral Changes After Methyltestosterone Administration
Open Access
- 1 February 2001
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 58 (2) , 172-177
- https://doi.org/10.1001/archpsyc.58.2.172
Abstract
ANABOLIC ANDROGENIC steroid (AAS) abuse poses a significant public health problem and has been associated with a range of psychiatric symptoms, including psychosis,1 irritability and aggression,2 and major mood syndromes.3 In a previous study of normal men,4 we demonstrated that even short-term administration of the AAS methyltestosterone (MT) produced significant mood and behavioral symptoms. Two subsequent blind, placebo-controlled studies5,6 confirmed the ability of such steroids to induce mood and behavioral symptoms in both normal volunteers and AAS users. The mechanisms underlying the development of AAS-induced psychiatric symptoms remain largely undetermined.Keywords
This publication has 1 reference indexed in Scilit:
- Cerebrospinal fluid somatostatin and psychiatric illnessBiological Psychiatry, 1986