The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick diseae.
- 1 February 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 55 (2) , 366-369
- https://doi.org/10.1073/pnas.55.2.366
Abstract
The level of the enzyme which catalyzes the hydrolysis of sphingomyelin has been determined in tissue samples from patients with Niemann-Pick disease and compared with tissue specimens from other human sources. It appears that the metabolic lesion In the classic infantile form of Niemann-Pick disease is attributable to a drastic attenuation or loss of activity of the enzyme which catalyzes the cleavage of sphingomyelin.Keywords
This publication has 4 references indexed in Scilit:
- Metabolism of glucocerebrosides II. Evidence of an enzymatic deficiency in Gaucher's diseaseBiochemical and Biophysical Research Communications, 1965
- Sphingomyelin Synthesis in Niemann-Pick DiseaseThe American Journal of Clinical Nutrition, 1961
- Rapid Sensitive Method for Determining H3-Water in Body Fluids by Liquid Scintillation Spectrometry.Experimental Biology and Medicine, 1959
- Phosphorylcholine in rat tissuesBiochemical Journal, 1955