Effect of Galactose-1-Phosphate on Glucose Oxidation by Normal and Galactosemic Leukocytes
- 14 October 1960
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 132 (3433) , 1015-1016
- https://doi.org/10.1126/science.132.3433.1015
Abstract
During incubation with galactose, galactosemic leukocytes accumulated more galactose-l-phosphate than did normal leukocytes. Concomitant determination of glucose oxidation, with C14 glucose, revealed no inhibition of the hexosemonophosphate pathway. These results are at variance with recent studies in rat lens tissue, which suggests that intracellular galactose-1-phosphate depressed glucose-6-phosphate dehydrogenase activity and the oxidative pathway.Keywords
This publication has 13 references indexed in Scilit:
- A STUDY OF SUBJECTS WITH ERYTHROCYTE GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY. II. INVESTIGATION OF LEUKOCYTE ENZYMES*Journal of Clinical Investigation, 1959
- Enzymatic Factors in Experimental Galactose CataractScience, 1959
- Prophylaxis of Poisoning by Carbon TetrachlorideNature, 1959
- Defect in Uptake of Galactose-1-Phosphate into Liver Nucleotides in Congenital GalactosemiaScience, 1957
- Studies on the Fibrinogen, Dextran and Phytohemagglutinin Methods of Isolating LeukocytesBlood, 1956
- Congenital Galactosemia, a Single Enzymatic Block in Galactose MetabolismScience, 1956
- Some disturbances of erythrocyte metabolism in galactosaemiaBiochemical Journal, 1956
- Galactose 1-phosphate in galactose cataractBiochimica et Biophysica Acta, 1955
- Carbohydrate metabolism of LensArchives of Ophthalmology (1950), 1955
- Comparative Effects of the Different Formed Elements on Normal Human Blood GlycolysisJournal of Applied Physiology, 1953