Pantothenic Acid Deficiency and Conjugation Reactions. III. Inhibitory Effect of -Methylpantothenic Acid.
- 1 November 1950
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 75 (2) , 352-354
- https://doi.org/10.3181/00379727-75-18195
Abstract
An analog of pantothenic acid, the Na salt of N(alpha,gamma-dihydroxy-beta,beta-dimethylvaleryl)-beta-alanine (termed omega-methylpantothenic acid) prevented pantothenic acid-deficient rats from responding normally to Ca pantothenate as measured by an acetylation test using sulfanilamide. When 140 mg. of the analog was administered over a period of 3 days, only a small response was noted; 230 mg. over a 6-day period prevented any response. After the analog was withdrawn and pantothenic acid administered, the animals exhibited a marked increase in acetylation.Keywords
This publication has 1 reference indexed in Scilit:
- COENZYME FOR ACETYLATION, A PANTOTHENIC ACID DERIVATIVEJournal of Biological Chemistry, 1947