Syntheses of gallic acid and pyrogallol
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 14,p. 1400-1401
- https://doi.org/10.1039/p19750001400
Abstract
Condensation of trimethyl propane-1,2,3-tricarboxylate (I) with dimethyl dimethoxymalonate (II) gave the cyclic β-keto-ester (III) and a smaller amount of a phenolic acid (IV). Treatment of the ester (III) with acid yielded gallic acid. Condensation of dimethyl glutarate with the diester (II) yielded the cyclic β-keto-ester (V), which was converted into 4,5,6-trihydroxyisophthalic acid (IX) on treatment with acid. The latter decarboxylated smoothly at 200 °C to give pyrogallol.Keywords
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