The concentrative nucleoside transporter family (SLC28): new roles beyond salvage?
- 1 February 2005
- journal article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 33 (1) , 216-219
- https://doi.org/10.1042/bst0330216
Abstract
The concentrative nucleoside transporter (CNT) family (SLC28) has three members: SLC28A1 (CNT1), SLC28A2 (CNT2) and SLC28A3 (CNT3). The CNT1 and CNT2 transporters are co-expressed in liver parenchymal cells and macrophages, two suitable models in which to study cell cycle progression. Despite initial observations suggesting that these transporter proteins might contribute to nucleoside salvage during proliferation, their subcellular localization and regulatory properties suggest alternative roles in cell physiology. In particular, CNT2 is a suitable candidate for modulation of purinergic responses, since it is under the control of the adenosine 1 receptor. Increasing evidence also suggests a role for CNT2 in energy metabolism, since its activation relies on the opening of ATP-sensitive K+ channels. Animal and cell models genetically modified to alter nucleoside transporter expression levels may help to elucidate the particular roles of CNT proteins in cell physiology.Keywords
This publication has 40 references indexed in Scilit:
- Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cellsJournal of Hepatology, 2004
- Distribution of CNT2 and ENT1 transcripts in rat brain: selective decrease of CNT2 mRNA in the cerebral cortex of sleep-deprived ratsJournal of Neurochemistry, 2004
- ATP-Sensitive K+ Channels Regulate the Concentrative Adenosine Transporter CNT2 following Activation by A1 Adenosine ReceptorsMolecular and Cellular Biology, 2004
- Functional and Genetic Diversity in the Concentrative Nucleoside Transporter, CNT1, in Human PopulationsMolecular Pharmacology, 2004
- Interferon-γ regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathwaysBiochemical Journal, 2003
- Macrophages require different nucleoside transport systems for proliferation and activationThe FASEB Journal, 2001
- Differential Expression and Regulation of Nucleoside Transport Systems in Rat Liver Parenchymal and Hepatoma CellsHepatology, 1998
- Regulation of Nucleoside Transport by Lipopolysaccharide, Phorbol Esters, and Tumor Necrosis Factor-α in Human B-lymphocytesPublished by Elsevier ,1998
- Nucleoside and nucleobase transport systems of mammalian cellsBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1996
- Early induction of Na+‐dependent uridine uptake in the regenerating rat liverFEBS Letters, 1993