Citric acid production by resorbing bone in tissue culture

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Abstract
The media from resorbing mouse calvaria in tissue culture were analyzed for citric acid, calcium, phosphorus, lactic acid, protein, sodium, glucosamine and mucoprotein "tyrosine." Paralleling the resorption of bone seen morphologically, increases in citric acid, calcium and phosphorus were observed. With the exception of lactic acid no changes in other constituents were noted. The cumulative increase in citric acid was 8–19 times greater than the total citric acid content of the original calvaria. It is concluded that the resorbing bone is capable of producing citric acid metabolically, a concept which has until now lacked direct evidence.

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