SUCCESSFUL TREATMENT OF ADVANCED ISONIAZID- AND STREPTOMYCIN-RESISTANT PULMONARY TUBERCULOSIS WITH ETHIONAMIDE, PYRAZINAMIDE, AND ISONIAZID

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Abstract
A re-treatment regimen using ethionamide and pyrazinamide was evaluated in 70 patients with advanced isoniazid-and streptomycin-resistant pulmonary tuberculosis. Reversal of infectiousness was observed in 53.4% of 43 patients who completed 3 to 18 months of therapy. The continued use of isoniazid enhances the effectiveness of ethionamide and pyrazinamide. Reversal of infectiousness was observed in 69% of patients receiving ethionamide-pyrazinamide-isoniazid for 3 months or more. Ethionamide gastro -intestinal toxicity has been troublesome. Pyrazinamide hepatotoxicity has not been serious so far.