Cerebral oedema after MDMA ("ecstasy") and unrestricted water intake

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# Values for plasma osmolality may have been wrong {#article-title-2} EDITOR,—S M Matthai and colleagues report two cases of cerebral oedema associated with the syndrome of inappropriate secretion of antidiuretic hormone after ingestion of 3, 4-methylenedioxymethamphetamine (MDMA or “ecstasy”).1 Their letter is, however, somewhat misleading. In case 1 the patient was reported to have a plasma sodium concentration of 119 mmol/l and a plasma osmolality of 156 mmol/kg. Some time later the urine sodium concentration was 6 mmol/l and urine osmolality 655 mmol/kg. In …

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