Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons
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- 1 January 2001
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 4 (1) , 38-43
- https://doi.org/10.1038/82881
Abstract
In contrast to peripheral nerves, damaged axons in the mammalian brain and spinal cord rarely regenerate. Peripheral nerve injury stimulates neuronal expression of many genes that are not generally induced by CNS lesions, but it is not known which of these genes are required for regeneration. Here we show that co-expressing two major growth cone proteins, GAP-43 and CAP-23, can elicit long axon extension by adult dorsal root ganglion (DRG) neurons in vitro. Moreover, this expression triggers a 60-fold increase in regeneration of DRG axons in adult mice after spinal cord injury in vivo. Replacing key growth cone components, therefore, could be an effective way to stimulate regeneration of CNS axons.Keywords
This publication has 48 references indexed in Scilit:
- Nogo in nerve regenerationNature, 2000
- Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1Nature, 2000
- Glial inhibition of nerve regeneration in the mature mammalian CNSGlia, 1999
- Comparing Astrocytic Cell Lines that Are Inhibitory or Permissive for Axon Growth: the Major Axon-Inhibitory Proteoglycan Is NG2Journal of Neuroscience, 1999
- Robust Regeneration of Adult Sensory Axons in Degenerating White Matter of the Adult Rat Spinal CordJournal of Neuroscience, 1999
- Intrinsic neuronal determinants that promotes axonal sprouting and elongationBioEssays, 1997
- Expression of the growth-associated protein GAP-43 in adult rat retinal ganglion cells following axon injuryNeuron, 1991
- Axonal Growth-Associated ProteinsAnnual Review of Neuroscience, 1989
- Elevated synthesis of an axonally transported protein correlates with axon outgrowth in normal and injured pyramidal tractsJournal of Neuroscience, 1986
- Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systemsThe Journal of cell biology, 1981