A General Solution for the 2‐Pyridyl Problem
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- 27 January 2012
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 51 (11) , 2667-2672
- https://doi.org/10.1002/anie.201108608
Abstract
Problem solved: An air‐stable 2‐pyridyl borane that can effectively couple to a wide range of aryl and heteroaryl halides and pseudohalides has evaded the synthesis community for decades. The discovery that Cu(DEA)2 powerfully enables palladium‐mediated cross‐couplings with air‐stable boronates 1 has finally provided a general solution to this problem. DEA=diethanolamine, DMF=N,N′‐dimethylformamide, Tf=trifluoromethanesulfonyl.Keywords
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