Bidirectional axonal transport of thallium in frog sciatic nerve

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Abstract
Bidirectional axonal transport of radioactivity was demonstrated in frog sciatic nerve in vitro and in vivo after local application of the Tl isotope 204Tl+ to the nerve. The transport rate was similar in both directions and about 30 mm/day at 18.degree. C. The transport was depressed by 2,4-DNP [2,4-dinitrophenyl], low-temperature and vinblastine. A somewhat larger amount of radioactivity was transported in the retrograde than in the anterograde direction. The possibility that K+ is in part replaced by Tl+, which is transported bound to organelles, e.g. mitochondria, will be considered. Tl might be a useful tool for future studies of axonal transport.