THYROIDITIS FOLLOWING ADMINISTRATION OF THYROID-STIMULATING HORMONE*

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Abstract
The administration of 10 units of one lot of commercial thyroid-stimulating hormone (TSH) on two successive mornings to 21 healthy male adults produced acute thyroiditis in 10 of them. The thyroiditis was not accompanied or followed by the appearance of antibody reacting with the TSH used or with an extract of normal human thyroid, as measured by precipitin or hemagglutinin titers in serum. Hence these cases of acute thyroiditis did not appear to belong in the group of auto-immune reactions as seen in chronic thyroiditis. The occurrence of thyroiditis enhanced the net thyroidal uptake of I131 at forty-eight hours and raised the 24-hour and 48-hour conversion ratios (serum PBI131 as a percentage of the total serum radioactivity). Both groups of patients, i.e., those with and without thyroiditis, manifested comparable increases in the serum PBI level. These increases, on the average, were of the order of magnitude observed in subjects given another lot of TSH which did not produce thyroiditis.

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