Antifungal Action of Rifampin
- 1 July 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 5 (Supplement) , S614-S619
- https://doi.org/10.1093/clinids/5.supplement_3.s614
Abstract
Rifampin and amphotericin B were found to be synergistic in vitro against Saccharomyces cerevisiae, Histoplasma capsulatum, and several species of Aspergillus, The uptake of rifampin by the fungi was increased in the presence of amphotericin B, and this increase probably formed the basis for the synergistic activity observed. In vivo, the combination proved more effective than either drug alone against experimental infections with H. capsulatum, Blastomyces dermatitidis, and Aspergillus species.Keywords
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