Combined Neoplastic Effects of Vaccinia Virus and 3-Methylcholanthrene. III. Susceptibility and Resistance in Transplanted Mouse Skin2

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Abstract
In cortisone-pretreated mice, susceptibility to the acute, local effects of vaccinia virus was correlated with susceptibility to the neoplastic effects of 3-methylcholanthrene (MCA) painting. To determine the relative importance of local versus systemic factors in these responses, susceptibility and resistance to both agents were investigated in transplanted skin. (BALB/c × AKR)F1 hybrids, susceptible to both agents, received skin grafts from either resistant AKR or even more highly susceptible BALB/c parental mice. Control groups included isografted AKR, BALB/c, and (BALB/c × AKR)F11 mice. After the grafts had healed, the mice first received cortisone and then vaccinia virus inoculated intradermally into the graft. MCA was then painted over both the grafted and adjacent host skin. Since vaccinia virus infection spread into the host skin, the acute effects of the virus and the neoplastic effects of the carcinogen could be observed in both graft and host skin. Isografting did not modify the responses of the skin. In F1 mice bearing AKR skin, the graft remained resistant to both agents and the surrounding host skin remained susceptible to both; in hybrids bearing BALB/c skin, the grafts and the host skin were susceptible to both agents. These findings indicate that susceptibility or resistance to both vaccinia virus and MCA painting is determined by local rather than systemic factors, presumably at the level of the target cell.

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