Pathobiochemistry of CO poisoning
- 15 October 1990
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 272 (1-2) , 1-6
- https://doi.org/10.1016/0014-5793(90)80436-m
Abstract
A hypothesis for the pathobiochemical mechanism of CO poisoning, amenable to in vivo testing with optical reflectance spectrophotometry, is presented. It differs from the classical formulation in which loss of cytochrome c oxidase function is attributed entirely to O2 depletion, by including ligation and oxygenation of CO as essential components of the inhibitory process.Keywords
This publication has 43 references indexed in Scilit:
- Carbon monoxide and oxygen binding to human hemoglobin F0Biochemistry, 1989
- Carbon monoxide binding to human hemoglobin A0Biochemistry, 1987
- Oxygenation of carbon monoxide by bovine heart cytochrome c oxidaseBiochemistry, 1986
- Oxygen Gradients During Hypoxie Steady States in Liver. Urate Oxidase and Cytochrome Oxidase as Intracellular O2IndicatorsHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1977
- Carbon monoxide binding studies of cytochrome α3 hemes in intact rat liver mitochondriaBiochemistry, 1971
- THE EQUILIBRIUM OF CARBON MONOXIDE WITH HUMAN HEMOGLOBIN IN WHOLE BLOODAnnals of the New York Academy of Sciences, 1970
- Rate at which CO replaces O2 from O2Hb in red cells of different speciesRespiration Physiology, 1969
- Rate of O2 dissociation from O2Hb and relative combination rate of CO and O2 in mammals at 37 °CRespiration Physiology, 1969
- Carbon Monoxide-Induced Arterial HypoxemiaScience, 1969
- Carboxyhemoglobin: Hemodynamic and Respiratory Responses to Small ConcentrationsScience, 1965