Histiocytic Medullary Reticulosis
- 1 October 1965
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 116 (4) , 589-593
- https://doi.org/10.1001/archinte.1965.03870040103021
Abstract
IN 1939 Scott and Robb-Smith1studied a group of the reticuloses which had previously been described as "atypical Hodgkin's disease" or "lymphadenoma verum." Out of this study came a distinct clinicopathologic entity which they named "histiocytic medullary reticulosis." They reported four cases and referred to six other probable cases which were characterized by fever, wasting, generalized lymphadenopathy associated with hepatosplenomegaly, and in the final stage jaundice, purpura, and anemia with profound leukopenia. Histologically there was systematized hyperplasia of histiocytes actively engaged in erythrophagocytosis. In 1961 Zak and Rubin2reported a case of histiocytic medullary reticulosis and reviewed 25 other cases. They found no sex predominance, and the age range was from 26 to 78 years with a mean of 48 years. Survival ranged from 1 to 15 months with a median of 5½ months. Three types of histiocytes were described; one had a pale, vesicular, elongated nucleus andThis publication has 0 references indexed in Scilit: