Conditions required for the antibacterial activity of zidovudine

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Abstract
In a study to determine the conditions required for its antibacterial activity, zidovudine was found to be bactericidal againstEscherichia coli andSalmonella typhimurium in nutrient broth over 6 h. Zidovudine was also found to be active against ten clinical isolates ofSalmonella andEscherichia coli at 1 mg/l, which is a clinically achievable concentration of the drug. Bacterial protein synthesis was required for the bactericidal activity of zidovudine against bothEscherichia coli andSalmonella typhimurium. Zidovudine was found to be inactive against non-dividing bacteria, as it was unable to kill bacteria of either species when they were suspended in PBS.