Syntheses of novel 25-hydroxyvitamin D3 haptens having chemical bridges at the C-11? position
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 1,p. 31-37
- https://doi.org/10.1039/p19930000031
Abstract
The serum or plasma levels of 25-hydroxyvitamin D31a is useful for the evaluation of vitamin D status in various clinical or nutritional disorders. To obtain antibodies to compound 1a which are highly specific and useful for development of immunoassays, two novel haptenic derivatives, 11α-(3-carboxypropionyloxy)-25-hydroxyvitamin D32a and 11α-(4-carboxybutyryloxy)-25-hydroxyvitamin D32b were synthesized each in 21 steps from 11α-hydroxydehydroepiandrosterone 3.Keywords
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