Effects of chloramphenicol and caffeine on postreplication repair in uvrA − umuC −and uvrA − recF −strains of Escherichia coli K-12
- 1 January 1977
- journal article
- conference paper
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 156 (2) , 115-120
- https://doi.org/10.1007/bf00283483
Abstract
Postreplication repair and its inhibition by chloramphenicol and caffeine, as seen in alkaline sucrose gradients, were compared between a UV nonmutable strain uvrA − umuC −and normally mutable strains uvrA − recF −and uvrA − umu + rec +of Escherichia coli K-12. The uvrA − umuC −strain performed postreplication repair as efficiently as the parental strain, while the repair in uvrA − recF −strain was dependent on UV dose. Both chloramphenicol and caffeine inhibited postreplication repair to an equal extent of about 25%, and 10%, respectively, in all three uvrA −strains of umuC36, recF −and umu + rec +. These observations suggest that postreplication repair is largely not responsible for UV mutagenesis.This publication has 28 references indexed in Scilit:
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