Kinetics of oral trifluoperazine disposition in man.

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Abstract
The disposition of trifluoperazine (TFP) was studied in five healthy volunteers following oral administration of a 5 mg tablet. Using a very sensitive GC‐MS technique plasma TFP concentrations were measured up until 24 h following drug ingestion. Peak plasma concentrations varied widely (range 0.53‐3.09 ng ml‐1) and were reached 2.8 +/‐ 0.5 h following ingestion of the TFP tablet. The apparent terminal elimination half‐life of TFP was 12.5 +/‐ 1.4 h. The area under the plasma concentration‐time curve differed widely between subjects (range: 5.9‐17.6 ng ml‐1 h) suggesting large individual differences in the extent of presystemic TFP elimination.