DNA Segmentation Through the Bayesian Approach
- 1 February 2000
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Computational Biology
- Vol. 7 (1-2) , 215-231
- https://doi.org/10.1089/10665270050081487
Abstract
We present a new approach to DNA segmentation into compositionally homogeneous blocks. The Bayesian estimator, which is applicable for both short and long segments, is used to obtain the measure of homogeneity. An exact optimal segmentation is found via the dynamic programming technique. After completion of the segmentation procedure, the sequence composition on different scales can be analyzed with filtration of boundaries via the partition function approach.Keywords
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