Power sequencing

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Abstract
Advances in DNA-sequencing technology provide unprecedented insight into the entire collection of four genomes' transcribed sequences. They herald a new era in the study of gene regulation and genome function. Until recently, it was thought that much of a genome sequence is silent for much of the time. Now a study in the fission yeast Schizosaccharomyces pombe, using recently developed DNA sequencing technologies, shows that almost all of the yeast genome is genetically active. More than 90% of the genome is transcribed into RNA, including more than 450 newly discovered transcripts, many of them non-coding, with regulatory or other unknown roles.