Study of Mitomycin C-induced chromosomal exchange
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Chromosoma
- Vol. 56 (1) , 1-13
- https://doi.org/10.1007/bf00293724
Abstract
Mitomycin C-induced sister chromatic exchange and quadriradial formation were studied in chromosomes from Muntiacus muntjac fibroblasts and A9, a transformed mouse cell line. We present the first direct cytological evidence for the induction of true somatic recombination involving homologous chromosomes. Analysis of the quadriradials from Muntjac cells indicates a non-random distribution with respect to the chromosomes involved and with respect to the points of conjunction. Sister chromatid exchange and quadriradial formation may reflect the outcome of repair processes involving a high frequency of homologous exchanges in the interphase nucleus.This publication has 24 references indexed in Scilit:
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