Stereocontrolled synthesis of Ψ[CH=CH] dipeptide isosteres
- 1 September 1991
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 38 (3) , 237-241
- https://doi.org/10.1111/j.1399-3011.1991.tb01434.x
Abstract
A new Stereocontrolled synthesis of the Ψ[CH=CH] dipeptide isostere is described. They key step of the sequence relies on the stereospecific α‐alkylation of δ‐amino‐γ‐mesyloxy‐α,β‐unsaturated esters. The broad availability of nucleophilic α‐side chains by this method allows the preparation of a wide variety of Ψ[CH=CH] isosteres with predictable stereochemistry.Keywords
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