Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction
- 30 January 2005
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 15 (5) , 1515-1520
- https://doi.org/10.1016/j.bmcl.2004.12.061
Abstract
No abstract availableKeywords
This publication has 17 references indexed in Scilit:
- In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2Science, 2004
- Inhibiting the p53–MDM2 interaction: an important target for cancer therapyNature Reviews Cancer, 2003
- Live or let die: the cell's response to p53Nature Reviews Cancer, 2002
- Isolation and Structure Elucidation of Chlorofusin, a Novel p53-MDM2 Antagonist from a Fusarium sp.Journal of the American Chemical Society, 2001
- Discovery of Potent Antagonists of the Interaction between Human Double Minute 2 and Tumor Suppressor p53Journal of Medicinal Chemistry, 2000
- Mdm2 association with p53 targets its ubiquitinationOncogene, 1998
- Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation DomainScience, 1996
- p53, guardian of the genomeNature, 1992
- Amplification of a gene encoding a p53-associated protein in human sarcomasNature, 1992
- The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivationCell, 1992