Peptide sweeteners. 7. Taste relationships of trifluoroacetyl-L-aspartylanilides
- 1 December 1984
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 27 (12) , 1668-1672
- https://doi.org/10.1021/jm00378a024
Abstract
A series of analogs of trifluoroacetyl-.alpha.-L-aspartylanilides substituted at various positions on the aromatic ring was synthesized and tasted. The position of the substitution is essential for the nature of the taste response. The close relationship between sweet and bitter taste for these compounds was established. Combined electronic and topochemical contributions were discussed.This publication has 2 references indexed in Scilit:
- Interaction of conformationally flexible agonists with the active site of sweet taste. A study of arylureasJournal of Medicinal Chemistry, 1983
- Peptide sweeteners. 3. Effect of modifying the peptide bond on the sweet taste of L-aspartyl-L-phenylalanine methyl ester and its analogsJournal of Medicinal Chemistry, 1980