Metabolism of Reserpine-C14. II. Species Differences as Studied in vitro
- 1 November 1955
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 90 (2) , 437-440
- https://doi.org/10.3181/00379727-90-22058
Abstract
Reserpine-Cl4 was incubated with liver slices of rat, mouse, guinea pig, rabbit and pigeon. C14O2 and trimethoxybenzoic acid-Cl4 (TMBA) productions were measured. Rat liver slices were most active in the demethylation and oxidation of the 4-methoxy carbon of TMBA moiety to C14O2 while guinea pig liver slices were most active in liberation of TMBA-C14. The microsomes were the main site of the esteratic activity. No correlation was seen between species variation in dose requirement of reserpine and degradative properties of their liver slices.Keywords
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