• 1 September 1971
    • journal article
    • Vol. 21  (3) , 455-61
Abstract
The present report describes the morphology of lymphoid tissues and the humoral antibody response during primary and secondary immune responses to sheep erythrocytes (SRBC) in Snell-Bagg hereditary pituitary dwarf mice. It has been found that while 19S primary response was depressed to a great extent, 7S secondary response reached practically normal levels. Histological studies of the peripheral lymphoid tissues have shown patterns of cellular depletion in nonthymus-dependent areas in dwarfs killed during primary response, while these areas appeared markedly cellular after a second antigenic stimulation.