G protein‐coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions
- 23 June 1998
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 430 (1-2) , 37-40
- https://doi.org/10.1016/s0014-5793(98)00495-5
Abstract
G protein-coupled receptor kinase 2 (GRK2) plays a key role in determining the rate and extent of G protein-coupled receptor (GPCR) desensitization and resensitization. Recent data indicate that GRK2 activity, subcellular distribution and expression are tightly regulated. The important physiological function of GRK2 as a modulator of the efficacy of GPCR signal transduction systems is exemplified by its relevance in cardiovascular physiopathology as well as by its emerging role in the regulation of chemokine receptors.Keywords
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