ALBENDAZOLE AS A FASCIOLICIDE IN EXPERIMENTALLY INFECTED SHEEP

  • 1 January 1977
    • journal article
    • research article
    • Vol. 38  (6) , 807-808
Abstract
The new drug albendazole (methyl [5-(propylthio)-1H-benzimidazol-2-yl]carbamate) was tested in 90 sheep experimentally infected with Fasciola hepatica. Dose rates of 10, 15 and 20 mg/kg of body weight were active against adult flukes, with efficacies of 98, 95 and 100%, respectively. The drug was less active against immature F. hepatica at 3 wk after sheep were inoculated. The drug given at dose rates of 20, 30, 40 and 50 mg/kg had efficacies 24, 47, 63 and 76%. Flukes were not found at posttreatment hour 48 in bile ducts of sheep given a dose of 20 mg/kg. Evidence of drug toxicity was not seen.