Testosterone Treatment in Adolescent Boys with Constitutional Delay in Growth and Development

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Abstract
The administration of androgens to adolescent boys with constitutional delay in growth has been highly controversial because of the possibility of premature epiphyseal closure and reduced final height. We have treated 15 such boys with a mean (±SD) age of 14.1±1.0 years and a mean initial height of 142.2±8.6 cm (range, 127.1 to 156.2). The boys received monthly intramuscular injections of testosterone enanthate (50 mg) for 1.2±0.3 years.