Autoantibodies from Vasectomized Guinea Pigs Inhibit Fertilization in Vitro
- 11 September 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 213 (4513) , 1267-1269
- https://doi.org/10.1126/science.7268435
Abstract
Immunoglobulin G and Fab antibodies were isolated from the serum of vasectomized guinea pigs, and the effects of the antibodies on fertilization in vitro were investigated. These antibodies had profound inhibitory effects on (i) sperm-to-sperm adhesion, (ii) the acrosome reaction, (iii) sperm-zona binding, and (iv) sperm-ovum fusion. This finding may explain certain cases of infertility after vasovasostomy in men.This publication has 14 references indexed in Scilit:
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