CORTICOSTERONE AND METHYLATION OF NORADRENALINE BY EXTRAADRENAL CHROMAFFIN TISSUE

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Abstract
SUMMARY: The effects of corticosterone and deoxycorticosterone in concentrations of 10 and 30 μ./ml. on organ cultures of extra-adrenal chromaffin cells of neonatal rabbits were investigated. The presence of corticosterone resulted in synthesis and storage of about 35% of adrenaline. Deoxycorticosterone did not induce methylation so that the ratio of catecholamines remained at about 90% noradrenaline. The results indicate the importance of the 11-oxy group in steroid-induced methylation of catecholamines.

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