Binding of perazine to ?1-acid glycoprotein

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Abstract
The high-affinity binding of perazine to human serum-protein (non-albumin binding) was previously investigated by gel-chromatography. The immunoelectrophoretic identification of the binding agent as α1-acid glycoprotein is described here. It was demonstrated by equilibrium dialysis that the average free fraction of3H-perazine added to 22 sera from patients before neuroleptic treatment was 3.67±0.42%, and that there was a significant correlation between the α1-acid glycoprotein content and the free fraction in these serum samples. This result is in accordance with what others have found for impramine. It is suggested that the nature of this binding should be studied in more detail, since specific binding to α1-acid glycoprotein may be related to the receptor binding of perazine and possibly other drugs.