Antifertility Effects of Benzylphenols and Benzyl-1,3-Benzodioxoles on Screwworm Flies12

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Abstract
Five compounds from structurally-modified, biologically active plant materials were evaluated for their antifertility effect on Cochliomyia hominivorax (Coquerel). When 0- to 5-day-old flies were treated orally with concentrations of 0.01–1.0% of three and 0.1–1.0% of two of the compounds, complete sterility of female flies was obtained, whereas only J2644 (2,4-bis (1,1-dlmethylethyl)-6-(4-methoxyphenylmethyl)phenol) affected fertility of males. The sterilants did not adversely affect the insemination and fecundity rates, and only the highest dosages of J2706, (2,4-bis(1,1-dimethylethyl)-6-(1-phenylethyl)phenol), J2693 (5-(2-propenyl)-6-(methoxyphenylmethyl)-1,3-benzodioxole), and J2581 (5-ethoxy-6-(4-methoxy-phenylmethyl)-1,3-benzodioxole), (1.0%) proved lethal to the flies. J2419 (2,4-bis(1,1-dimethylethyl)-6-(phenylmethyl)phenol, or J2644 continued to be effective up to the 3rd gonotrophic cycle when most of the flies were already dead. Exposure to 0.25% of J2644 for the 1st 24 or 48 h halved or eliminated fertility, respectively. Increasing dosages by 4-fold did not significantly affect efficiency of the chemosterilants. Single meals of 1.0% J2644 or of J2419 were effective in giving complete sterility.

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