Immune-Complex-Mediated Biologic Effects

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Abstract
COMPLEXES of antigen and antibody (immune complexes) are capable of causing inflammatory injury.1 Many human diseases can now be attributed to the presence of immune complexes in tissues. Some examples are systemic lupus erythematosus, acute and chronic glomerulonephritis, rheumatoid arthritis, vasculitis, and tissue injury associated with a variety of infectious agents.Immune complexes are formed by the union of one or more antibody molecules with one or more antigen molecules. Once formed, the complex may activate cellular and humoral mediator systems that cause tissue injury.The means by which immune complexes develop in tissues has been determined in several experiments. . . .

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