Detection of reciprocal fusion 5′‐BCL6/partner‐3′ transcripts in lymphomas exhibiting reciprocal BCL6 translocations

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Abstract
It has been believed that replacement of the endogenous promoter and the non‐coding first exon of the BCL6 gene by a sequence derived from the translocational partner gene is a main mechanism of the BCL6 dysregulation resulting from translocation. In this study, we found that reciprocal BCL6 translocation led to the expression of not only the 5′‐partner/BCL6–3′ fusion transcripts but also the 5′‐BCL6/partner‐3′ fusion transcripts, suggesting that reciprocal 5′‐BCL6/partner‐3′ fusion genes are transcriptionally active. These findings raise the possibility that reciprocal BCL‐6 translocation may lead to dysregulation of the partner gene as well as the BCL6 gene.