1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D 3 in the Intestine
- 2 July 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 173 (3991) , 51-54
- https://doi.org/10.1126/science.173.3991.51
Abstract
The major polar metabolite of cholecalciferol (vitamin D3) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C27H4403 and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this (laboratory) probably represents the biologically active form of cholecalciferol in the intestine.Keywords
This publication has 16 references indexed in Scilit:
- Studies on calciferol metabolism II. Tritium loss from tritiated vitamin D3 and the possible structure of the proposed nuclear regulator of intestinal calcium transportSteroids, 1971
- Identification of 1,25-Dihydroxycholecalciferol, a New Kidney Hormone controlling Calcium MetabolismNature, 1971
- Studies on calciferol metabolism I. Production of vitamin D metabolite 4B from 25-OH-cholecalciferol by kidney homogenatesBiochemical and Biophysical Research Communications, 1971
- Vitamin D: A Cholecalciferol Metabolite Highly Active in Promoting Intestinal Calcium TransportScience, 1971
- Unique Biosynthesis by Kidney of a Biologically Active Vitamin D MetaboliteNature, 1970
- Metabolism and subcellular location of 25-hydroxycholecalciferol in intestinal mucosaBiochemistry, 1970
- In vitro production of 25-hydroxycholecalciferolBiochemical and Biophysical Research Communications, 1969
- CHROMOSOMAL RECEPTOR FOR A VITAMIN D METABOLITEProceedings of the National Academy of Sciences, 1969
- 25-Hydroxycholecalciferol. A biologically active metabolite of vitamin D3Biochemistry, 1968
- THE MODE OF ACTION OF VITAMIN DBiological Reviews, 1968