Incidence of Resistant Pulmonary Tuberculosis in Relation to Initial Bacterial Load

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Abstract
Mice harbouring a measured load of cul-turable Mycob. bovis in the lungs were treated either with rifampicin or INH in high doses over prolonged periods of time. Observed differences in the ultimate incidence of resistant infections were related to the assessed number of resistant units of mycobacteria which were present at the start of the treatment. It followed that the superior efficacy of rifampicin was based on the fact that the bacterial population used for the infection contained approx. 200 times less rifampicin-resistant than INH-resistant bacterial units. There was no indication of a difference in the infectivity of the rifampicin- and INH-resistant mutants in this bacterial strain.

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