Enzymatic and Non-Enzymatic Formation of Free Radicals From Aflatoxin B1
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research Communications
- Vol. 10 (3) , 137-142
- https://doi.org/10.3109/10715769009149882
Abstract
Formation of free radicals from aflatoxin B1 was demonstrated in systems of a) NADPH/microsome, b) H2O2/peroxidase, c) UV irradiation, d) silver oxide oxidation and e) alkaline dimethyl sulfoxide. In a) to c), radical spots were detected in thin-layer chromatograms. Among several known metabolites of aflatoxin B1, aflatoxin M1 was active in generation of free radical. These results suggest a possible role of free radical metabolites in the cytotoxicity of this hepatocarcinogen.Keywords
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